Erythrocyte Separation Using Gravitational Field Flow Effect
نویسندگان
چکیده
This research aims to simulate a gravity flow fractionation—the process to fractionate erythrocytes through gravitational field using ANSYS simulation software. A particular microfluidic channel was designed as a separation device. The gravitational equilibrium conditions of the erythrocytes and gravitational field as the parameters were chosen, then deriving the erythrocytes’ path through numerical simulations. After the actual analog measurements, there is no big difference between the flow velocity and the pressure under +/−10% atmosphere condition. According to the simulation results, the particle with the size 8 μm (similar to the erythrocyte size) can be separated to the outside channel and discharged from the collecting area, other particles with the size 9 μm will stay in the fluid motion and can be collected in the final collection area for preservation. Through the analog analysis by using the software-ANSYS-Fluent, the complete flowing path of the particles and the feasibility of the Gravity-Flow Fractionation can be directly proven.
منابع مشابه
CFD Investigation of Gravitational Sedimentation Effect on Heat Transfer of a Nano-Ferrofluid
In the present attempt, flow behavior and thermal convection of one type of nanofluids in a disc geometry was investigated using Computational Fluid Dynamics (CFD). Influence of gravity induced sedimentation also has been studied. The commercial software, Fluent 6.2, has been employed to solve the governing equations. A user defined function was added to apply a uniform external ma...
متن کاملMiniature field-flow fractionation system for analysis of blood cells.
Field-flow fractionation is an analytical tool that has been historically used to separate species, ranging from molecules to particles or cells several micrometers in size. This technology can effect separation by size, density, charge, or other physical properties, depending on the configuration of the field-flow system. We have developed a miniature field-flow system to analyze cell populati...
متن کاملA Novel Indicator to Predict the Onset of Instability of a Gravitational Flow on a Slope
In order to present a quantitative indicator for the onset of instability, in this paper, the critical points of a stratified gravitational flow on a slope are found and analyzed. These points are obtained by means of the solution of the two-dimensional Navier-Stokes equations via the standard Arakawa-C finite-difference method. Results show that in the marginal Richardson numbers, the critical...
متن کاملCeramic Processing Research Investigation of porous graphite formation during milling process by gravitational field flow fractionation and Brunauer-Emmett-Teller techniques
Field flow fractionation is a family of separation techniques applicable to characterize various particulate materials of different nature. In this paper, formation of porous graphite during milling has been investigated by gravitational field flow fractionation. The results from gravitational field flow fractionation were compared to those from Brunauer-Emmett-Teller. The both techniques have ...
متن کاملGravitational Field-Flow Fractionation Devices Fabricated via a Hot Embossing/Thermal Bonding Method
A novel hot embossing/low temperature ethanol solvent bonding method for the fabrication of polymethylmethacrylate (PMMA) field flow fractionation devices has been developed. The separation channel on a PMMA substrate was generated by a hot embossing process without vacuum. Special temperature-pressure profiles were used to analyze the influence of the hot embossing parameters. After the hot em...
متن کامل